Disorder in proper neural circuit formation during development is thought to underlie the pathogenesis of schizophrenia and neurodevelopmental diseases. Neural circuits are shaped by activity-dependent elimination of unnecessary synapses during postnatal development. This process is known as synapse elimination and is widely considered to be a critical step in creating mature neural circuits. Neural activity has been shown to be essential for synapse elimination, but the underlying mechanisms remain largely unknown.
Professor Masanobu Kano and his colleagues at the Graduate School of Medicine have reported that the immediate early gene Arc, one of a class of genes that respond transiently and rapidly to cellular stimuli, mediates activity-dependent synapse elimination in the developing cerebellum. First, they showed that the elevation of Purkinje cell activity in the mouse cerebellum accelerated climbing fiber synapse elimination. Then, they elucidated that the expression of Arc induced by Ca2+ influx into Purkinje cells was crucial for the acceleration of synapse elimination. Furthermore, they demonstrated that Arc is essential for accomplishing synapse elimination by removing the redundant climbing fiber synapses on the cell bodies of Purkinje cells.
Disordered expression of Arc has recently been reported in several mouse models of neurodevelopmental diseases, including Fragile X syndrome and tuberous sclerosis. This study may provide a new approach to unraveling the pathogenesis of such diseases in the light of synapse elimination.
http://www.marpolephysio.com | Marpole Physiotherapy & Rehabilitation Clinic provides all treatments with a highly-skilled physiotherapist trained in the latests evidence-based techniques for your optimal recovery. The goal is to regain optimum health with an effective manual treatment for a faster recovery and educate the patient in their own rehabilitation.
http://www.marpolephysio.com | Marpole Physiotherapy & Rehabilitation Clinic provides a very experienced team of physiotherapists to manage general, occupational and sports-related problems. Our clinic includes a fully equipped gym for rehabilitation of injuries, and to introduce patients to the correct and safe use of gym equipment. We also have a series of beginner to intermediate pilates classes taught by a physiotherapist.
Finally went to the physio to treat my shin splints from too much running. Apparently my muscle composition were what were causing the extra stress on my left shin. Treatment consisted of some massage and my first bout of electrical acupuncture and walking out of there with kinesio tape on my leg. So attractive right? Oh well, just having it for two days. Hope to recover soon, I miss running.